Essentials in Lung Transplantation by Allan R. Glanville

Author:Allan R. Glanville
Language: eng
Format: epub, pdf
ISBN: 9783319909332
Publisher: Springer International Publishing

10.2 Diagnosis of Infections

The risk of infection is much higher after lung transplantation than in any other solid organ transplant, and early detection of occult infection may lead to better outcomes [23–25]. Anastomotic infections can be secondary to necrosis, colonization, or aspiration. Due to their state of immune suppression patients are susceptible to both common airway pathogens as well as numerous rarer bacterial, viral, and fungal infections that often arise from the normal flora of the donor or recipient airway [26], with bacterial infections most likely in the first few weeks after lung transplantation [27]. With increasing population movement we may see the increased incidence of donor-derived infections such as tuberculosis which may be detected during surveillance bronchoscopies prior to clinical sequelae [28]. Although most patients undergoing bronchoscopy for diagnosis of infection will be doing so in order to obtain microbiological samples and would be clinically symptomatic at the time of bronchoscopy, up to one third of patients may be asymptomatic and harbouring infection [29]. This is most common in the 3–12 month period post lung transplantation [3].

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